PREGNANT WOMAN WITH DIFFUSE TOXIC GOITRE
Kalit so'zlar:
pregnancy, diffuse toxic goiter, newborns, thyroidAnnotatsiya
The influence of diffuse toxic goiter on the course and outcome of pregnancy was studied. 67 pregnant women with diffuse toxic goiter were examined. The comparison group consisted of 38 pregnant women without thyroid pathology. The examination included determination of free thyroxine, TSH, autoantibodies to the TSH receptor and thyroid peroxidase in the blood of pregnant women and umbilical cord blood, as well as ultrasound of the thyroid gland of newborns and the TSH/free ratio. T4. In women with unresolved thyrotoxicosis, pregnancy and childbirth were more often complicated by the threat of miscarriage, gestosis, chronic placental insufficiency, fetal malnutrition and hypoxia, and untimely rupture of amniotic fluid. The high frequency of subclinical hypothyroidism (more than 50%) in newborns is associated with the transplacental transfer of thyreostatic drugs. Subclinical hyperfunction of the thyroid gland in 17% of newborns should be associated with the transplacental transfer of autoantibodies to the TSH receptor from mother to fetus.
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