HYPOTHYROIDIS IS A PROBLEM OF THE XXI ERA
Keywords:
hypothyroidism, autoimmune thyroiditis, TSH, thyroid hormones, drug-induced hypothyroidism, replacement therapy, levothyroxineAbstract
The article reflects issues of epidemiology, classification, and clinical picture of hypothyroidism. The incidence of hypothyroidism increases significantly with age. The most common form is primary hypothyroidism, caused by a pathological process in the thyroid gland itself. Secondary or tertiary hypothyroidism is caused by insufficient secretion of thyroid-stimulating hormone (TSH), or thyrotropin-releasing hormone. The article discusses the main causes of primary and secondary hypothyroidism. The most common cause of primary hypothyroidism is autoimmune thyroiditis, which can develop either separately or simultaneously with other autoimmune diseases, as part of polyglandular syndrome. Changes in thyroid status as a consequence of adverse side reactions when using a number of drugs deserve special attention. Questions have been raised about the mechanisms of development of thyroid failure as a result of adverse side reactions when using a number of drugs (lithium preparations, iodine-containing compounds, tyrosine kinase inhibitors, etc.).
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Copyright (c) 2024 Daminov Abdurasul Taxirovich, G`olibjon O`ktamjonov, Sarvinoz Allayorova , Hilola Sanaqulova , Sunnat Ergashev
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